(He Shou Wu in Chinese pinyin, hereinafter referred to as HSW) is the root ofPolygonum multiflorum, a member of Polygonaceae. hypoleucum It is native to Central and southern China. A standard dose in the Chinese Pharmacopoeia is 3 to 12 g/day. The genus primarily grows in northern temperate regions. He Shou Wu is a Chinese herbal medicine, derived from the Polygonum multiflorum Thunb plant ().. Polygonum multiflorum Thunb. Of the 130 related cases of liver injury related to supplements, 65% were from non-bodybuilding supplements and occurred most often in Hispanic/Latinos compared to non-Hispanic whites and non-Hispanic blacks. Evidence exists of hepatic injury in humans. hypoleucum, Fallopia multiflorum var. In the Middle English glossary of herbs Alphita (c. 1400-1425), it was known as ars-smerte. It is native to central and southern China. As of February 2019[update], Plants of the World Online accepted 129 species. There are usually four to six stamens and three (rarely two) styles. The processed root has been used to lower cholesterol levels in Traditional Chinese Medicine. There are no clinical data regarding the use of P. multiflorum in cancer. Haraldson. Polygonum is a genus in the Polygonaceae family. Polygonum multiflorum Thunb. hypoleucum, syn. P. multiflorum is used at daily doses of 9 to 15 g of raw herb, but clinical studies are lacking. Embryonic toxicity has been reported.53, Case reports are lacking. The genus name is usually said to be from the Greek πολυ- (poly-, 'many') and γόνυ (gonu, 'knee' or 'joint'), in reference to the swollen jointed stem. Free and Open Access to Biodiversity Data. .mw-parser-output table.clade{border-spacing:0;margin:0;font-size:100%;line-height:100%;border-collapse:separate;width:auto}.mw-parser-output table.clade table.clade{width:100%;line-height:inherit}.mw-parser-output table.clade td.clade-label{width:0.7em;padding:0 0.15em;vertical-align:bottom;text-align:center;border-left:1px solid;border-bottom:1px solid;white-space:nowrap}.mw-parser-output table.clade td.clade-fixed-width{overflow:hidden;text-overflow:ellipsis}.mw-parser-output table.clade td.clade-fixed-width:hover{overflow:visible}.mw-parser-output table.clade td.clade-label.first{border-left:none;border-right:none}.mw-parser-output table.clade td.clade-label.reverse{border-left:none;border-right:1px solid}.mw-parser-output table.clade td.clade-slabel{padding:0 0.15em;vertical-align:top;text-align:center;border-left:1px solid;white-space:nowrap}.mw-parser-output table.clade td.clade-slabel:hover{overflow:visible}.mw-parser-output table.clade td.clade-slabel.last{border-left:none;border-right:none}.mw-parser-output table.clade td.clade-slabel.reverse{border-left:none;border-right:1px solid}.mw-parser-output table.clade td.clade-bar{vertical-align:middle;text-align:left;padding:0 0.5em;position:relative}.mw-parser-output table.clade td.clade-bar.reverse{text-align:right;position:relative}.mw-parser-output table.clade td.clade-leaf{border:0;padding:0;text-align:left}.mw-parser-output table.clade td.clade-leafR{border:0;padding:0;text-align:right}.mw-parser-output table.clade td.clade-leaf.reverse{text-align:right}.mw-parser-output table.clade:hover span.linkA{background-color:yellow}.mw-parser-output table.clade:hover span.linkB{background-color:green}, Polygonum ciliinode (syn. Between 65[8] and 300 species have been recognised at various times, depending on the circumscription of the genus. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Embryonic toxicity has been reported. Fallopia multiflora (Thunb.) Polygonum multiflorum, Helxine multiflorum, Pleuroptterus cordatus, Polygonum convolvulus, Polygonum multiflorus Common Names Chinese Knotweed, Climbing Knotweed, Fo ti, Flowery Knotweed, He-Shou-Wu, Kashuu When the genus is defined narrowly, Polygonum species are annual or perennial herbaceous plants, rarely shrubby, with much branched stems. In Traditional Chinese Medicine, fleeceflower root is prepared by cleaning, slicing and drying and then steaming it in black soybean juice. Emodin has demonstrated inhibitory effects on vasodilation in isolated rat aortas.25 Tetrahydroxystilbene glucoside has been shown to exert a number of actions, including prevention of reperfusion injury in human umbilical endothelial cells,26 prevention of oxidized low-density, lipoprotein-induced endothelial dysfunction,27 reduction of vascular smooth muscle cell production in response to cellular injury,28and antiplatelet activity in response to collagen-induced aggregation.29. Powders are great for encapsulating. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Ho-shou-wu (pinyin: heshouwu) is derived from the roots of Polygonum multiflorum.The herb was first recorded (1,2,16) in the Ri Huazi Bencao (Tang Dynasty, 713 A.D.) and then incorporated into the well-known Kaibao Bencao (Song Dynasty; 973 A.D.). Hepatotoxicity has been documented.50, 51, 52 GI symptoms, including diarrhea, may be due to consuming raw or improperly processed fo-ti.4, Data collected between 2004 and 2013 among 8 US centers in the Drug-induced Liver Injury Network revealed 15.5% (130) of hepatotoxicity cases was caused by herbals and dietary supplements whereas 85% (709) were related to medications. Polygonum is a genus of about 130 species of flowering plant in the buckwheat and knotweed family Polygonaceae. Contains some soy. Get you gone, dwarf;You minimus, of hindering knot-grass made; Genus of flowering plants in the knotweed family Polygonaceae, See the preparation of one particular dish in Turkey using. Within the tribe, it is most closely related to the genera Duma and Atraphaxis, forming the so-called "DAP clade". Common names include knotweed and knotgrass (though the common names may refer more broadly to plants from Polygonaceae). This information relates to an herbal, vitamin, mineral or other dietary supplement. Molecular phylogenetic studies, particularly in the 21st century, have led to major changes. Fo-Ti is believed to als… Origin: China. Other genera, such as Polygonella, have been subsumed into Polygonum. The leaves are arranged alternately, usually less than 2 cm (0.8 in) long, with a length greater than the width. It is in flower from July to September. View abstract. For example, buckwheat (Fagopyrum esculentum) has sometimes been included in the genus as Polygonum fagopyrum. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In vitro studies in tissues of the CNS report decreased neuroinflammation via inhibition of microglia activation,30 promotion of hippocampal synaptic plasticity,31 antioxidant effect in hippocampal and other cells,32, 33, 34, 35 and the reduction of amyloid peptide production.36 In contrast, an in vitro study using cultured mouse cortical neurons showed an extract of P. multiflorum to be neurotoxic.37 In a study conducted in rats, tetrahydroxystilbene glucoside reversed impaired learning and memory; histological changes were observed in the hippocampus.38, P. multiflorum extracts are traditionally used in Ayurvedic medicine and in traditional Chinese medicine for the treatment of cognitive disorders; however, clinical studies are lacking.37 One study conducted among patients with Alzheimer disease (N = 209) reported that the extract was effective; details of the methodology are unclear.39, Effects on triglyceride and total cholesterol regulation have been demonstrated by tetrahydroxystilbene glucoside, emodin, and physcion in mice and in vitro.40, 41, 42, 43 Raw fo-ti appeared to be more effective than processed fo-ti in 1 study.41, There are no clinical data regarding the use of P. multiflorum in dyslipidemia; however, both raw and cured fo-ti are used in traditional Chinese medicine for dyslipidemia.4, In vitro studies have shown that extracts of P. multiflorum possess antioxidant properties.30, 35, 37, 44, 45, 46, 47, 48 Immunomodulatory and anti-inflammatory effects have also been reported.5 Reduction in the production of glycation end products in diabetes has been demonstrated in vitro.49, In contrast to the known hepatotoxicity of P. multiflorum extracts,50, 51, 52 tetrahydroxystilbene glucoside and emodin appear to have hepatoprotective effects.30, 32, 43, 48, P. multiflorum is used at daily doses of 9 to 15 g of raw herb, but clinical studies are lacking. Click below on a thumbnail map or name for species profiles. This information should not be used to decide whether or not to take this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. : 823837 (Download Help) Polygonum multiflorum TSN 823837 Taxonomy and Nomenclature Kingdom: Plantae : Taxonomic Rank: Species : Common Name(s): tuber fleeceflower [English] Accepted Name(s): Fallopia multiflora (Thunb.) Haraldson – tuber fleeceflower. Polygonum hydropiper is a ANNUAL growing to 0.8 m (2ft 7in). Botanical names: Polygonum multiflorum How It Works The major constituents of fo-ti are anthraquinones, phospholipids (e.g., lecithin), tannins, and tetrahydroxystilbene glucoside. Clinical trials reporting on efficacy are limited.4, A mixture including he shou wu has been studied for its effects on the glucocorticoid receptor in senile rat thymocytes.15 An effect of emoghrelin, derived from P. multiflorum, stimulated growth hormone in vitro,16 and tetrahydroxystilbene glucoside protected against the thinning of mice derma associated with aging.17 Lifespan and lipid studies of he shou wu in quails have been performed.18, There are no clinical data regarding the use of P. multiflorum for antiaging effects. The plant may also be nephro-, neuro-, and embryotoxic. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Prepare as a tea or tonic, or as directed by a physician. [12] The species Polygonum cognatum, known locally as "madimak",[13][14] is regularly consumed in central parts of Turkey. Avoid use. Overall, the number of severe liver injury cases was significantly higher from supplements than conventional medications (P=0.02). by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon. Care should be taken not to confuse Polygonum with Polygonatum – an entirely different genus of plants. Sorting Polygonum names. Of the 217 supplement products implicated in liver injury, fo-ti was among the 22% (116) of the single-ingredient products.55, Reviews of the toxic effects, possibly dose- and duration-related, of P. multiflorum on the liver have been published. Protective effect of Polygonum multiflorum Thunb on amyloid beta-peptide 25-35 induced cognitive deficits in mice. Not be used to lower cholesterol levels in Traditional Chinese Medicine reports are lacking its polygonum multiflorum common name hepatotoxic, Kim,. Between 65 [ 8 ] and 300 species have been moved to other genera, such as Polygonella have! 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